ChemicalBook--->CAS DataBase List--->27740-01-8

27740-01-8

27740-01-8 Structure

27740-01-8 Structure
IdentificationMore
[Name]

Scutellarin
[CAS]

27740-01-8
[Synonyms]

7-(beta-d-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
SCUTELLAREIN 7-O-GLUCURONIDE
SCUTELLARIN
SCUTELLARIN, 98+% BY HPLC
(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2-
4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone
4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid
5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid
Scutellarein 4'-methyl ether 7-glucuronide
Scutellarein 7-glucuronide
[EINECS(EC#)]

1806241-263-5
[Molecular Formula]

C21H18O12
[MDL Number]

MFCD01861503
[Molecular Weight]

462.36
[MOL File]

27740-01-8.mol
Chemical PropertiesBack Directory
[Melting point ]

300~301℃
[Boiling point ]

891.6±65.0 °C(Predicted)
[density ]

1.810±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMSO (Slightly), Methanol (Very Slightly, Sonicated)
[form ]

neat
[pka]

2.72±0.70(Predicted)
[color ]

Light Yellow to Yellow
[BRN ]

71779
[CAS DataBase Reference]

27740-01-8(CAS DataBase Reference)
Safety DataBack Directory
[Safety Statements ]

24/25
[WGK Germany ]

3
[HS Code ]

29389090
Hazard InformationBack Directory
[Description]

Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911). Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.
[Uses]

Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascula r diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
[Definition]

ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.
Spectrum DetailBack Directory
[Spectrum Detail]

Scutellarin(27740-01-8)1HNMR
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