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473382-39-7

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473382-39-7 Structure

473382-39-7 Structure
IdentificationBack Directory
[Name]

N3-(7-Cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-1,3-propanediamine
[CAS]

473382-39-7
[Synonyms]

Akt-l-1
Akt-I-1
Akt-I-1 (Akti-1)
N1-(7-Cyclobutyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N3,N3,2,2-tetramethylpropane-1
N3-(7-Cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-1,3-propanediamine
N1-(7-Cyclobutyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-N3,N3,2,2-tetramethylpropane-1,3-diamine
1,3-Propanediamine, N3-(7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-
1,3-PropanediaMine, N'-(7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N,N,2,2-tetraMethyl- (9CI)
[Molecular Formula]

C22H30N6
[MDL Number]

MFCD16038643
[MOL File]

473382-39-7.mol
[Molecular Weight]

378.51
Chemical PropertiesBack Directory
[density ]

1.20
[solubility ]

Ethanol: Sparingly Soluble: 1-10 mg/ml
Hazard InformationBack Directory
[Uses]

Akt-I-1 is a reversible inhibitor of serine/threonine protein kinase AKT, and has been shown to induce apoptosis in LNCap prostate cancer cells.
[IC 50]

Akt1: 4.6 μM (IC50); Akt2: >250 μM (IC50); Akt3: >250 μM (IC50)
[References]

[1] STANLEY F BARNETT. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.[J]. Biochemical Journal, 2005, 385 Pt 2: 399-408. DOI: 10.1042/bj20041140
Spectrum DetailBack Directory
[Spectrum Detail]

N3-(7-Cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-1,3-propanediamine(473382-39-7)1HNMR
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