| Identification | Back Directory | [Name]
3-[[3-[(DIMETHYLAMINO)CARBONYL]-2-HYDROXYPHENYL]AMINO]-4-[[(R)-1-(4-ISOPROPYLFURAN-2-YL)PROPYL]AMINO]CYCLOBUT-3-ENE-1,2-DIONE | [CAS]
473728-58-4 | [Synonyms]
SCH 563705
SCH563705; SCH-563705
3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(4-isopropylfuran-2-yl)propyl]amino
3-[[3-[(DiMethylaMino)carbonyl]-2-hydroxyphenyl]aMino]-4-[[(R)-1-(4-isopropylfuran-2-yl)propyl]aMino]cyclobut-3-ene-1
3-[[3,4-Dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
3-[[3-[(DIMETHYLAMINO)CARBONYL]-2-HYDROXYPHENYL]AMINO]-4-[[(R)-1-(4-ISOPROPYLFURAN-2-YL)PROPYL]AMINO]CYCLOBUT-3-ENE-1,2-DIONE
Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]- | [Molecular Formula]
C23H27N3O5 | [MOL File]
473728-58-4.mol | [Molecular Weight]
425.48 |
| Chemical Properties | Back Directory | [Boiling point ]
555.9±60.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
7.93±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide is a CXCR2/CXCR1 antagonist that has therapeutic potential for targeting CXCR2/CXCR1 in human arthritides. | [in vivo]
SCH 563705 has good oral pharmacokinetic profiles in rats, mice, monkeys and dogs[1]. SCH 563705 (50 mg/kg p.o) reduces blood Ly6G+ Ly6C+ neutrophil frequency and unchanged levels of Ly6GLy6Chi monocytes. SCH563705 (3-30 mg/kg p.o) treatment causes a dosedependent elevation in plasma levels of CXCL1[2]. | [IC 50]
CXCR2: 1 nM (Ki); CXCR1: 3 nM (Ki); CXCR2: 1.3 nM (IC50); CXCR1: 7.3 nM (IC50); Mouse CXCR2: 5.2 nM (IC50) |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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