| Identification | Back Directory | [Name]
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL | [CAS]
474711-89-2 | [Synonyms]
BUTTPARK 85\04-05
Piperazine-1-carboxylic acid amid
1-piperazinecarboxamide hydrochloride
Piperazine-1-carboxamide hydrochloride
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL ISO 9001：2015 REACH | [Molecular Formula]
C5H12ClN3O | [MDL Number]
MFCD06408948 | [MOL File]
474711-89-2.mol | [Molecular Weight]
165.62 |
| Chemical Properties | Back Directory | [Melting point ]
221-224°C | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C5H11N3O.ClH/c6-5(9)8-3-1-7-2-4-8;/h7H,1-4H2,(H2,6,9);1H | [InChIKey]
UVYKKFKLOUEFAR-UHFFFAOYSA-N | [SMILES]
C(N1CCNCC1)(=O)N.Cl |
| Hazard Information | Back Directory | [Uses]
Piperazine-1-carboxamide Hydrochloride is used in preparation of heteroaromatic derivatives as PDE4 inhibitors. | [Synthesis]
General procedure for the synthesis of piperazine-1-amide hydrochloride from tert-butyl 4-carbamoylpiperazine-1-carboxylate: To a dichloromethane (DCM, 2 mL) solution of tert-butyl 4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) was added an ethyl acetate (EtOAc) solution of hydrochloric acid (4 M, 2 mL). The reaction mixture was stirred at room temperature for 30 min and then concentrated under reduced pressure to give piperazine-1-amide hydrochloride as a white solid (0.16 g, 100% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 3.71-3.73 (m, 4H), 3.25-3.27 (m, 4H); MS-ESI: m/z 130.10 [M + H - HCl]+. | [References]
[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00403
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1050; 1054-1056
[3] Patent: EP1593679, 2005, A1. Location in patent: Page/Page column 59 |
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