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474960-44-6

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474960-44-6 Structure

474960-44-6 Structure
IdentificationBack Directory
[Name]

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
[CAS]

474960-44-6
[Synonyms]

CS-1139
SB 657510
2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxy-phenyl]-4,5-dimethoxy-benzenesulfonamide
BenzenesulfonaMide, 2-broMo-N-[4-chloro-3-[[(3R)-1-Methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-diMethoxy-
[Molecular Formula]

C19H22BrClN2O5S
[MDL Number]

MFCD16618389
[MOL File]

474960-44-6.mol
[Molecular Weight]

505.81
Chemical PropertiesBack Directory
[Boiling point ]

585.0±60.0 °C(Predicted)
[density ]

1.512±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

DMSO: ≥30mg/mL
[form ]

powder
[pka]

6.60±0.10(Predicted)
[color ]

white to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

SB 657510 is a selective GPR14 (urotensin-II (UT) receptor) antagonist.
[Biological Activity]

SB 657510 slows development of diabetes-associated atherosclerosis in mouse model of diabetes.1 ''SB-657510 is a selective urotensin-II (UT) receptor antagonist. Human urotensin-II (hU-II) is proposed to play a significant role in cardiorenal and metabolic disease statesincluding heart failureatherosclerosishypertension.
[in vivo]

SB-657510 inhibits the progression of high-fat diet induced atherosclerosis and diabetes-associated atherosclerosis[1].
Levels of phosphorylated ERK are significantly attenuated in the aorta of SB-657510-treated (30 mg/kg/day) diabetic mice (Male Apoe KO mice)[3].

[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide(474960-44-6)1HNMR
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