| Identification | Back Directory | [Name]
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate | [CAS]
476310-60-8 | [Synonyms]
VO Ohpic
VO-Ohpic
VO-OHpic (hydrate)
VO-OHpic trihydrate
VO-OHpic (PTEN Inhibitor)
VO-OHpic trihydrate >=98% (HPLC), solid
(OC-6-45)-aqua(3-Hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxovanadate(1-) hydrogen trihydrate
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate | [Molecular Formula]
C12H8N2O7V.3H2O | [MDL Number]
MFCD11045907 | [MOL File]
476310-60-8.mol | [Molecular Weight]
397.189 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
gray | [InChI]
InChI=1S/2C6H5NO3.3H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);3*1H2;;;/q;;;;;;+3;/p-3 | [InChIKey]
XSVSRTSHXJGGKW-UHFFFAOYSA-K | [SMILES]
O.O.C1=CN=C2C(=O)O[V]([H])(=O)(OC(=O)C3C(O)=CC=CN=3)OC2=C1.O |
| Hazard Information | Back Directory | [Uses]
VO-?OHPIC Trihydrate is used to inactivate tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (Pten) which induces a respons that opposes tumorigeneis. | [General Description]
VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells. | [Biochem/physiol Actions]
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor. | [in vivo]
PTEN is inhibited in mice by intra-peritoneal injection of VO-OHpic (10 μg/kg) 30 min before ischemia and then exposed them to 30 min of ischemia and 120 min of reperfusion. At the end of the experiment, myocardial infarct size is measured by triphenyltetrazolium chloride (TTC). Myocardial infarct size is significantly decreased in VO-treated mice (25±6 vs. 56±5 %, n=7, P<0.01). There is no difference in the area at risk between these two groups (46±3 vs. 57±3 %, n=7, P>0.05)[3]. | [storage]
Store at -20°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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