477953-07-4

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477953-07-4 Structure

Identification	Back Directory
[Name] Neostenine
[CAS] 477953-07-4
[Synonyms] Neostenine Furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one, 8-ethyldodecahydro-11-methyl-, (7aR,8R,8aR,11S,11aR,11bS,11cR)-
[Molecular Formula] C17H27NO2
[MOL File] 477953-07-4.mol
[Molecular Weight] 277.4

Hazard Information	Back Directory
[Uses] Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application[1][2].
[References] [1] Chung HS, et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 2003 Oct;69(10):914-20. DOI:10.1055/s-2003-45100 [2] Leung PH, et al. Intestinal absorption of Stemona alkaloids in a Caco-2 cell model. Planta Med. 2006 Feb;72(3):211-6. DOI:10.1055/s-2005-916195

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