| Identification | Back Directory | [Name]
(S)-BEL | [CAS]
478288-94-7 | [Synonyms]
(S)-BEL
(S)-BROMOENOL LACTONE
(3S,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
6E-(BROMOMETHYLENE)TETRAHYDRO-3-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3S,6E)- | [Molecular Formula]
C16H13BrO2 | [MDL Number]
MFCD08062191 | [MOL File]
478288-94-7.mol | [Molecular Weight]
317.18 |
| Chemical Properties | Back Directory | [Boiling point ]
467.0±45.0 °C(Predicted) | [density ]
1.538±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): .05 mg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 μM[1]. | [Definition]
ChEBI: (S)-Bromoenol lactone is a member of naphthalenes. | [IC 50]
PLA2 | [storage]
Store at -20°C, protect from light | [References]
[1] Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discriminati DOI:10.1074/jbc.M202568200 |
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