| Identification | Back Directory | [Name]
1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID | [CAS]
479553-01-0 | [Synonyms]
SWF-7
7-Azaindole-4-carboxylic ...
7-AZAINDOLE-4-CARBOXYLIC ACID
3-b]pyridine-4-carboxylic acid
7-Azaindole-4-carboxylicacid,97%
1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID | [Molecular Formula]
C8H6N2O2 | [MDL Number]
MFCD08272236 | [MOL File]
479553-01-0.mol | [Molecular Weight]
162.15 |
| Chemical Properties | Back Directory | [Melting point ]
>330℃ | [density ]
1.506±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
1.45±0.10(Predicted) | [color ]
White to cream | [InChI]
1S/C8H6N2O2/c11-8(12)6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)(H,11,12) | [InChIKey]
HPPPHDPVSYYWCH-UHFFFAOYSA-N | [SMILES]
OC(=O)c1ccnc2[nH]ccc12 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36 | [Safety Statements ]
26-24/25 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow solid | [Uses]
The sensitivity of 7-azaindole to its environment is demonstrated and then exploited by studying it and its analogs in peptides and in complexes with larger proteins containing many tryptophan residues. | [Synthesis]
General procedure for the synthesis of 7-azaindole-4-carboxylic acid from 4-cyano-7-azaindole: A mixture of 4-cyano-7-azaindole (11.5 g, 80 mmol), sodium hydroxide (32 g, 800 mmol), water (100 mL) and ethanol (100 mL) was heated to reflux. After 6 hours of reaction, the reaction mixture was cooled to room temperature, neutralized and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration to afford 7-azaindole-4-carboxylic acid (10.4 g, 80% yield), which was used in subsequent reactions without further purification. | [References]
[1] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 65
[2] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 52 |
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