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479630-08-5

479630-08-5 Structure

479630-08-5 Structure
IdentificationBack Directory
[Name]

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
[CAS]

479630-08-5
[Synonyms]

4-Piperidinepropanoic aci...
1-Boc-4-(2-Ethoxycarbonyl-acetyl)
4-(3-Ethoxy-3-oxopropanoyl)piperidine
BOC-4-(3-ETHOXY-3-OXOPROPAN OYL)PIPERIDINE
1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine
Ethyl 3-Oxo-3-(1-Boc-4-piperidyl)propanoate
N-BOC-4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE
1-Boc-b-oxo-4-piperidinepropanoic acid ethyl ester
4-(3-Ethoxy-3-oxopropanoyl)piperidine, N-BOC protected
N-(T-BUTOXYCARBONYL)-4-(2-ETHOXYCARBONYL-ACETYL) PIPERIDINE
TERT-BUTYL 4-(3-ETHOXY-3-OXOPROPANOYL)PIPERIDINE-1-CARBOXYLATE
tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxyla...
4-(3-ethoxy-1,3-dioxopropyl)-2-piperidinecarboxylic acid tert-butyl ester
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)tetrahydro-2H-pyridine-1-carboxylate
tert-butyl 4-(3-ethoxy-3-oxopropanoyl)tetrahydro-1(2H)-pyridinecarboxylate
1-[(1,1-Ddimethylethoxy)carbonyl]-b-oxo-(4-piperidinepropanoicacid ethyl ester
4-Piperidinepropanoicacid, 1-[(1,1-diMethylethoxy)carbonyl]-b-oxo-, ethyl ester
4-Piperidinepropanoic acid, 1-[(1,1-diMethylethoxy)carbonyl]-β-oxo-, ethyl ester
1-[(1,1-DiMethylethoxy)Carbonyl]-beta-Oxo-4-Piperidinepropanoic Acid Ethyl Ester
tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(3-ethoxy-3-oxopropanoyl)piperidine, Ethyl 3-[1-(tert-butoxycarbonyl)piperidin-4-yl]-3-oxopropanoate
[Molecular Formula]

C15H25NO5
[MDL Number]

MFCD04115569
[MOL File]

479630-08-5.mol
[Molecular Weight]

299.36
Chemical PropertiesBack Directory
[Boiling point ]

386.1±32.0 °C(Predicted)
[density ]

1.113±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[pka]

10.39±0.20(Predicted)
[Appearance]

White to off-white Solid
[CAS DataBase Reference]

479630-08-5
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xi
[Hazard Note ]

Irritant
[HazardClass ]

IRRITANT
[HS Code ]

29333990
Spectrum DetailBack Directory
[Spectrum Detail]

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(479630-08-5)1HNMR
Hazard InformationBack Directory
[Synthesis]

Ethanol

64-17-5

tert-butyl 4-(2,2-dimethyl-4,6-dioxo-1,3-dioxane-5-carbonyl)piperidine-1-carboxylate

1336874-02-2

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

479630-08-5

General procedure for the synthesis of tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate from ethanol and compound (CAS:1336874-02-2): tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (3) was added to anhydrous ethanol (200 mL) and the solution was refluxed for 48 hours. Upon completion of the reaction, the solution was concentrated under vacuum and purified by fast chromatography (eluent: dichloromethane) to afford the product 3 as a slightly reddish oil (14.36 g, 85% yield). The product characterization data were as follows: 1H NMR (500 MHz, CDCl3) δ 12.09 (s, 0.14H, allyl OH), 4.89 (s, 0.14H, allyl CH), 4.13 (q, J = 7Hz, 2H), 4.10-3.96 (m, 2H), 3.42 (s, 2H), 2.81-2.67 (m, 2H), 2.62-2.52 (m, 2H). 2.62-2.52 (m, 1H), 1.85-1.71 (m, 2H), 1.55-1.43 (m, 2H), 1.39 (s, 9H), 1.21 (t, J = 7Hz, 3H); 13C NMR (125 MHz, CDCl3) δ 204.0, 180.2 (alkenols), 172.7 (enol), 167.0, 154.4, 87.52, 79.51, 61.3, 48.5, 47.1, 28.2, 27.1, 13.9; thin-layer chromatography Rf = 0.2 (dichloromethane). High-resolution mass spectrometry (HRMS) calculated value C15H26NO5(M + H)+ 300.1805, measured value 300.1808.

[References]

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7193 - 7205
[2] Patent: WO2013/25939, 2013, A2. Location in patent: Page/Page column 69; 71
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