| Identification | More | [Name]
Isofraxidin | [CAS]
486-21-5 | [Synonyms]
6,8-DIMETHOXY-7-HYDROXYCOUMARIN
AKOS 243-93
ISOFRAXIDIN
ISOFRAXIDINE
7-hydroxy-6,8-dimethoxy-2h-1-benzopyran-2-on
7-hydroxy-6,8-dimethoxy-2h-1-benzopyran-2-one
7-hydroxy-6,8-dimethoxy-coumari
phytodolor
7-Hydroxy-6,8-dimethoxychromen-2-one
6,8-Dimethoxy-7-hydroxy-2H-1-benzopyran-2-one
7-Hydroxy-6,8-dimethoxycoumarin | [Molecular Formula]
C11H10O5 | [MDL Number]
MFCD00221757 | [Molecular Weight]
222.19 | [MOL File]
486-21-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
145～147℃ | [Boiling point ]
452.1±45.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 250 mg/mL (1125.16 mM) | [form ]
neat | [pka]
7.92±0.20(Predicted) | [color ]
Yellow to brown | [BRN ]
202652 | [InChI]
InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)11(15-2)9(7)13/h3-5,13H,1-2H3 | [InChIKey]
HOEVRHHMDJKUMZ-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=C(OC)C(O)=C(OC)C=C2C=C1 | [CAS DataBase Reference]
486-21-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in boiling water, difficult to dissolve in cold water, easily soluble in methanol, ethanol, and sodium hydroxide solution, derived from Sargassum scutellariae, Acanthopanax senticosus bark, and the whole plant of Sargassum glabra. | [Uses]
Isofraxidin is used as an anti-inflammatory compound. Inhibits pro-inflammatory cytokines. | [Definition]
ChEBI: Isofraxidin is a hydroxycoumarin. | [IC 50]
COX-2; TLR4; MMP-7 |
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