| Identification | Back Directory | [Name]
Propargyl-PEG1-t-butyl ester | [CAS]
488150-84-1 | [Synonyms]
Propargyl-PEG1-Boc
Propargyl-PEG1-COOtBu
Alkyne-PEG1-CH2CH2COOtBu
PROPARGYL-PEG1-CH2CH2COOTBU
Propargyl-PEG1-t-butyl ester
3-(2-Propyn-1-yloxy)propanoic acid tert-butyl ester
Propanoic acid, 3-(2-propyn-1-yloxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H16O3 | [MDL Number]
MFCD26793744 | [MOL File]
488150-84-1.mol | [Molecular Weight]
184.23 |
| Chemical Properties | Back Directory | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C10H16O3/c1-5-7-12-8-6-9(11)13-10(2,3)4/h1H,6-8H2,2-4H3 | [InChIKey]
VDHVLESCKRSEAF-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCC#C |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG1-t-butyl ester has a propargyl group and a t-butyl protected carboxyl group. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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