| Identification | Back Directory | [Name]
8-(8-chloro-5H-pyrimido[5,4-b]indol-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane | [CAS]
489402-33-7 | [Synonyms]
8-(8-chloro-5H-pyrimido[5,4-b]indol-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane | [Molecular Formula]
C17H17ClN4O2 | [MOL File]
489402-33-7.mol | [Molecular Weight]
344.8 |
| Hazard Information | Back Directory | [Uses]
UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 2.57 μM[1]. | [Definition]
ChEBI:8-(8-chloro-5H-pyrimido[5,4-b]indol-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane is an azaspiro compound and a pyrimido-indole. | [References]
[1] Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039. DOI:10.1172/JCI169039 |
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