| Identification | Back Directory | [Name]
2-[(4-chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]ethyl furan-2-carboxylate | [CAS]
591242-60-3 | [Synonyms]
2-[(4-chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]ethyl furan-2-carboxylate
2-Furancarboxylic acid, 2-[(4-chlorophenyl)(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]ethyl ester | [Molecular Formula]
C20H15ClN2O5S | [MOL File]
591242-60-3.mol | [Molecular Weight]
430.86 |
| Hazard Information | Back Directory | [Uses]
UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates[1]. | [References]
[1] Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039. DOI:10.1172/JCI169039 |
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