| Identification | Back Directory | [Name]
Glycyl-l-histidyl-l-lysine | [CAS]
49557-75-7 | [Synonyms]
GHK
GCU21P
CHK.Cu
Cu-GHK
Ahk-cu
GHK2-CU
TRIOEOTIDE-1
Cooper Peptide
Gly-His-Lys-Cu
Ghk-Cu Peptides
Copper peptides
Sansheng peptide
Blue copper peptide
Liver growth factor
H-Gly-His-Lys-OH：Cu
Blue-cupric peptide
Tripeptide-1 Copper
Copper Peptide AHK-Cu
(Gly-His-Lys)2Cu.xHAc
GHK Cu Copper Peptide
glycyl-histidyl-lysine
COPPER PEPTIDE(GHK-CU)
Copper peptide (GHK)
AHK-Cu (Copper Peptide)
Growth-modulating peptide
Glycyl--histidyl-l-lysine
Glycyl-L-Histidyl-L-Lysine
L-Lysine,glycyl-L-histidyl-
(GHK)2Cu, GHK-Cu, GHK Copper
Liver Cell Growth Factor(GHK)
Copper Tripeptide-1 (GHK-Cu)
Copper Peptide powder (GHK-cu)
GHKcu/Growth-Modulating peptide
Copper Peptide(GHK-Cu, GHK-Copper)
GHK Cu Copper Peptide GHK.Cu GHK-Cu
Glycyl-l-histidyl-l-lysine USP/EP/BP
Copper Tripeptide-1(GHK-Cu, GHK-Copper)
copper peptide (ghk-cu / copper peptide)
Lipopeptide Acetate / Palmitoyl Hexapeptide
Copper Peptide / Glycyl-L-Histidyl-L-Lysine
Growth-modulating peptide/Liver growth factor
ALANINE/HISTIDINE/LYSINEPOLYPEPTIDECOPPERHCL(1:1)
(S)-6-Amino-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid
(2S)-6-Amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C14H24N6O4 | [MDL Number]
MFCD00036754 | [MOL File]
49557-75-7.mol | [Molecular Weight]
340.378 |
| Chemical Properties | Back Directory | [Melting point ]
>144°C (dec.) | [Boiling point ]
831.0±65.0 °C(Predicted) | [density ]
1.324 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
3.11±0.10(Predicted) | [color ]
Off-White | [Sequence]
Copper gly-his-lys | [Stability:]
Hygroscopic | [InChIKey]
MVORZMQFXBLMHM-QWRGUYRKSA-N | [SMILES]
C(O)(=O)[C@H](CCCCN)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CN |
| Hazard Information | Back Directory | [Description]
Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine. | [Uses]
anti-wrikle | [Definition]
ChEBI: A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. | [Biological Functions]
When applied topically, copper peptide works as an antioxidant, promote collagen and elastin production, and soften the appearance of fine lines and wrinkles.
| [Pharmaceutical Applications]
Glycyl-l-histidyl-l-lysine (GHK) is a tripeptide known for its high binding affinity to Cu2+ and its complex
role in wound healing. The GHK–Cu(II) complex was isolated from human plasma in the 1970s and it was
shown to be an activator for wound healing. GHK–Cu(II) has two main functions: as an anti-inflammatory
agent to protect the tissue from oxidative damage after the injury, and as an activator for wound healing itself
as it activates the tissue remodelling.
The structure of GHK is very similar to that of common drugs used to treat ulcers.
After the initial stages of wound healing are activated, such as blood coagulation and neutrophil invasion, a
second stage of wound healing begins, which includes the population of GHK at the wound, which has a high
affinity to Cu2+. Mast cells, which are located in the skin, secrete GHK, which accumulates Cu2+ and forms
the copper complex GHK–Cu(II) and therefore increases the metal–tripeptide concentration at the wound.
First, GHK–Cu(II) has an anti-inflammatory effect by protecting the tissue from oxidative damage and by
suppressing local inflammatory signals (i.e. cytokine interleukin-1 (IL-1)). Second, GHK–Cu(II) is released
into the blood stream and encourages the production of wound macrophages that support the wound repair
by removing the damaged tissue and secreting a family of several growth factor proteins. GHK–Cu(II) also
hinders fibroblast production of TGF-β-1 and therefore suppresses the scar development. The GHK–Cu(II)
complex also stimulates the growth of blood vessels, neurons and elastin, and, in general, supports most
processes of wound healing.
| [Side effects]
While Copper Peptide Serum is generally safe to use, you should be aware of potential side effects that may occur. Although rare, some individuals may experience skin irritation or redness after applying the serum. This can be due to sensitivity to the ingredients or an allergic reaction.
Another potential side effect of Copper Peptide Serum is increased sensitivity to sunlight. The serum can make your skin more prone to sunburn. | [storage]
Store at -20°C | [References]
[1] MINHUA HONG . Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines[J]. Biochemical and biophysical research communications, 2025, 742: Article 151060. DOI:10.1016/j.bbrc.2024.151060.
[2] PICKART L. The human tri-peptide GHK and tissue remodeling.[J]. Journal of Biomaterials Science, Polymer Edition, 2008, 19 8: 969-988. DOI:10.1163/156856208784909435.
[3] HYE-RYUNG CHOI. Stem cell recovering effect of copper-free GHK in skin.[J]. Journal of Peptide Science, 2012, 18 11: 685-690. DOI:10.1002/psc.2455.
[4] XIAO-MING ZHOU. GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition.[J]. Frontiers in Pharmacology, 2017: 904. DOI:10.3389/fphar.2017.00904. |
|
| Company Name: |
MarsLab Gold
|
| Telephone: |
17549219037 17549219037 |
| Website: |
marslabbio.manus.space |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
AF Biochem Co., Ltd.
|
| Telephone: |
+86-028-60911900 13540204019 |
| Website: |
www.afbiochem.com |
|