| Identification | More | [Name]
GLY-HIS-LYS ACETATE SALT | [CAS]
72957-37-0 | [Synonyms]
GLYCYL-L-HISTIDYL-L-LYSINE ACETATE
GLY-HIS-LYS ACETATE
GLY-HIS-LYS ACETATE SALT
GLY-HIS-LYS ACOH H2O
H-GLY-HIS-LYS-OH ACETATE SALT
H-GLY-HIS-LYS-OH ACOH
LIVER CELL GROWTH FACTOR
LIVER CELL GROWTH FACTOR ACETATE SALT
LIVER-CELL GROWTH FACTOR ACOH H2O
N2-(N-glycyl-L-histidyl)-L-lysine monoacetate
GLY-HIS-LYS ACETATE CELL CULTURE TESTED
GLYCYL-L-HISTIDYL-L-LYSIN ACETAT HYDRAT
GLYCINE-L-HISTIDINE-L-LYSINE extrapure | [EINECS(EC#)]
277-125-4 | [Molecular Formula]
C16H28N6O6 | [MDL Number]
MFCD00012699 | [Molecular Weight]
400.43 | [MOL File]
72957-37-0.mol |
| Questions And Answer | Back Directory | [Synthesis]
Tripeptide-1 was synthesized via retrosynthetic analysis. First, according to the Noyori asymmetric reduction, tripeptide-1 (1) was retrograded to compound ketone 2; ketone 2 can be obtained from compound 4 by selective hydrosilanization to intermediate 3, and then 3 by Tamao-Fleming oxidation; fragment 4 can be cleaved into compounds 5, 6 and commercially available starting material 7, as shown in the figure below:
Then, according to the retrosynthetic analysis, tripeptide 1 was synthesized, and its synthetic route is shown below:
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| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
powder | [color ]
white | [biological source]
synthetic (organic) | [Water Solubility ]
H2O: soluble 0.5mg/mL, clear, colorless | [Sequence]
Gly-His-Lys | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
ANTIOXIDANT
SKIN PROTECTING | [InChIKey]
MGNUTAFMLGJBGV-ACMTZBLWSA-N | [SMILES]
C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r| | [CAS DataBase Reference]
72957-37-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Tripeptide-1 is a small peptide composed of three amino acids (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin. | [Chemical Properties]
White powder | [Uses]
Liver Cell Growth Factor | [General Description]
Gly-His-Lys is a tripeptide present at ～200ng/ml in association with α-globulin and albumin, in human blood plasma. | [Biochem/physiol Actions]
Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation. | [in vitro]
In an enzyme assay, the liver growth factor, Tripeptide-1, was hydrolyzed by an aminotripeptidase purified from rat brain cytosol[1]. | [in vivo]
Tripeptide-1 (1% in saline; dose = 10 mg/kg) was injected into the tail vein of male rats (number not specified). Blood samples were collected prior to dosing and for up to 60 minutes post-dosing. Plasma concentration-time profiles of Tripeptide-1 and its l-histidyl-l-lysine metabolite indicated that neither was detected in predose plasma samples. However, after intravenous (IV) injection, Tripeptide-1 was rapidly degraded to l histidyl-l-lysine, rapidly eliminated from circulating blood. It has been reported that Tripeptide-1 is unstable in human plasma and is rapidly degraded by aminopeptidases[1].
| [References]
[1] Wilbur Johnson. “Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics.” International Journal of Toxicology 37 1 (2018): 102S–90S.
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| Company Name: |
bociny Gold
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| Telephone: |
18939812306 |
| Website: |
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| Company Name: |
AF Biochem Co., Ltd. Gold
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| Telephone: |
+86-028-60911900 13540204019 |
| Website: |
www.afbiochem.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
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