| Identification | Back Directory | [Name]
oxyfenamate | [CAS]
50-19-1 | [Synonyms]
P-301
Al-0361
Listica
NSC-108034
oxyfenamate
Oxifenamate
Oxyphenamate
Hydroxyphenamate
(2-hydroxy-2-phenylbutyl) carbamate
(2-hydroxy-2-phenyl-butyl) carbamate
1,2-Butanediol, 2-phenyl-, 1-carbamate
carbamic acid (2-hydroxy-2-phenyl-butyl) ester | [EINECS(EC#)]
200-017-5 | [Molecular Formula]
C11H15NO3 | [MDL Number]
MFCD00868145 | [MOL File]
50-19-1.mol | [Molecular Weight]
209.24 |
| Chemical Properties | Back Directory | [Melting point ]
55-56.5° | [Boiling point ]
348.6°C (rough estimate) | [density ]
1.1547 (rough estimate) | [refractive index ]
1.5080 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO |
| Hazard Information | Back Directory | [Originator]
Listica,Armour,US,1961 | [Uses]
Tranquilizer (minor). | [Definition]
ChEBI: Oxyfenamate is an alkylbenzene. | [Manufacturing Process]
2-Phenyl-2-hydroxy-butyl carbamate was prepared by the following method:
49.81 g of 2-phenyl-1,2-butanediol and 25.01 g of pyridine were dissolved in
500 ml of benzene and cooled to 5°C. 34.01 g of ethyl chloroformate was
added over a period of 36 hour at 4°C to 8°C. The reaction mixture was
warmed to room temperature and stirred for 2 hours and then extracted with
100 cc each of the following:
Water, 15% hydrochloric acid, 10% sodium bicarbonate and finally water. The
solvent was stripped off. The residual oil was mixed with 300 ml of 28%
aqueous ammonia for 1 hour. The ammonia and water were vacuum distilled
at a temperature of 40°C or less. Then 300 cc of carbon tetrachloride was
added and the solution dried with sodium sulfate. The solution was cooled at
0°C and then filtered. The crystals were washed with cold carbon tetrachloride
and vacuum dried. The yield was 57 g of dried product having a melting point
of 55°C to 56.5°C. | [Therapeutic Function]
Tranquilizer |
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