| Identification | Back Directory | [Name]
Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- | [CAS]
500214-53-9 | [Synonyms]
ARC-111
Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 12-[2-(dimethylamino)ethyl]-2,3-dimethoxy- | [Molecular Formula]
C23H23N3O5 | [MDL Number]
MFCD08056235 | [MOL File]
500214-53-9.mol | [Molecular Weight]
421.45 |
| Hazard Information | Back Directory | [Uses]
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells[1]. | [IC 50]
Topoisomerase I | [References]
[1] Li TK, et al. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. Cancer Res. 2003 Dec 1;63(23):8400-7. PMID:14679002 |
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