| Identification | Back Directory | [Name]
PA-6 | [CAS]
500715-03-7 | [Synonyms]
PA-6 >=98% (HPLC)
1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane | [Molecular Formula]
C31H32N4O2 | [MDL Number]
MFCD31699851 | [MOL File]
500715-03-7.mol | [Molecular Weight]
492.61 |
| Chemical Properties | Back Directory | [Boiling point ]
648.1±65.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (253.75 mM) | [form ]
Solid | [pka]
8.61±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3]. | [Biological Activity]
PA-6 (Pentamidine-Analogue 6) is a selective and potent IK1 (inward rectifier potassium current) inhibitor th at terminates atrial fibrillation and does not cause ventricular arrhythmias in go at and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel. | [References]
[1] Takanari H, et al. Efficient and specific cardiac IK? inhibition by a new pentamidine analogue. Cardiovasc Res. 2013 Jul 1;99(1):203-14. DOI:10.1093/cvr/cvt103
[2] Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. DOI:10.1111/bph.13869
[3] Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44. DOI:10.1186/s12929-017-0352-x |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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