| Identification | Back Directory | [Name]
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea | [CAS]
501693-48-7 | [Synonyms]
TIE-2/VEGFR-2 kinase-IN-2
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Urea,N-[4-(4-aminofuro[2,3-α]pyrimidin-5-yl)phenyl]-N-[2-fluoro-5-(trifluoromethyl)phenyl]-
4-Amino-5-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]furo[2,3-d]pyrimidine | [Molecular Formula]
C20H13F4N5O2 | [MOL File]
501693-48-7.mol | [Molecular Weight]
431.343 |
| Hazard Information | Back Directory | [Uses]
TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2]. | [Biological Activity]
Cell permeable: yes''Primary Target
RIP1 Kinase | [IC 50]
Tie2: 8.56 nM (pIC50); VEGFR-2; Tie-2 | [References]
[1] Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. DOI:10.1016/j.bmcl.2006.12.077 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|