| Identification | Back Directory | [Name]
Niranthin | [CAS]
50656-77-4 | [Synonyms]
Niranthin
Pearlgrass
rac-Niranthin
9'-PentaMethoxy-3
4-Methylenedioxylignan
3',4',5,9,9'-PentaMethoxy-3,4-Methylenedioxylignan
1,3-Benzodioxole,6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-,rel-
6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole | [Molecular Formula]
C24H32O7 | [MDL Number]
MFCD09970365 | [MOL File]
50656-77-4.mol | [Molecular Weight]
432.51 |
| Chemical Properties | Back Directory | [Boiling point ]
559.5±50.0 °C(Predicted) | [density ]
1.142±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml | [InChI]
1S/C24H32O7/c1-25-13-18(8-16-6-7-20(27-3)21(10-16)28-4)19(14-26-2)9-17-11-22(29-5)24-23(12-17)30-15-31-24/h6-7,10-12,18-19H,8-9,13-15H2,1-5H3/t18-,19-/m0/s1 | [InChIKey]
RCFGIEPQSDGMJJ-OALUTQOASA-N | [SMILES]
COC1=C(OCO2)C2=CC(C[C@H](COC)[C@@H](COC)CC3=CC=C(OC)C(OC)=C3)=C1 |
| Hazard Information | Back Directory | [Uses]
rac-Niranthin is a lignan compound isolated from the plant Phyllanthus amarus and shows anti-leishmanial activity. It acts through induction of topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells triggering apoptosis of cellular nucleases. It also maintains the ability to reduce uric acid concentrations through xanthine oxidase inhibition. | [IC 50]
Leishmania; Topoisomerase | [storage]
Store at -20°C |
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