| Identification | Back Directory | [Name]
D-AMPHETAMINE SULFATE | [CAS]
51-63-8 | [Synonyms]
amdex
ardex
dadex
medex
tydex
zamine
dexten
amphex
afatin
albemap
acedron
dexalme
diocurb
evrodex
pomadex
revidex
duradex
pellcap
ephadren
phetadex
sympamin
tempodex
hetamine
lentanet
domafate
dexalone
carrtime
adjudets
adrizine
algo-dex
amsustain
diphylets
dephadren
obesedrin
recordati
dynaphenyl
pro-dexter
dextrosule
amphetasul
betafedrina
dellipsoids
psychodrine
simpamina-d
tuphetamine
(+)-amitrene
Betaphedrine
d-atephenyl747
d-betaphedrine
maxitonsulfate
dexedrinesulfate
Amphetaminesulfate
d-benzedrinesulfate
dexamfetaminesulfate
dexamphetaminesulfate
D-AMPHETAMINE SULFATE
d-amphetaminesulphate
(+)-amphetaminesulfate
dexamphetamine sulphate
(S)-Amphetamine sulfate
dextroamphetaminesulfate
DELTA-AMPHETAMINESULPHATE
D-AMphetaMine Sulfate (CII)
D-Amphetamine sulfate salt
.alpha.-Methyl-, sulfate,(+)
d-1-phenyl-2-aminopropanesulfate
d-beta-phenylisopropylaminesulfate
Dextroamphetamine hemisulfate salt
D-Amphetamine hemisulfate salt
d-amphetamine sulfate salt solution
d-alpha-methylphenethylaminesulfate
alpha-methylbenzeneethanaminesulfate
dextro-1-phenyl-2-amino-propanesulfate
Dextroamphetamine Sulfate CII (500 mg)
(+)-alpha-methylphenethylamine sulfate
dextro-beta-phenylisopropylaminesulfate
dextro-alpha-methylphenethylaminesulfate
phenethylamine,alpha-methyl-,sulfate,(+)
alpha-methylphenethylaminesulfate,d-form
(+)-α-Methylphenethylaminehemisulfatesalt
(+)-alpha-methylphenethylaminesulfate(2:1)
(S)-.alpha.-Methylbenzeneethanamine sulfate
D-amphetamine sulfate--dea schedule*ii item
D-Amphetamine hemisulfate salt solution
alpha-methyl-,sulfate(2:1),(+)-phenethylamin
(alphaS)-alpha-Methylbenzeneethanamine sulfate
S(+)-AMPHETAMINE SULFATE (DEXTROAMPHETAM INE SU
D-amphetamine sulfate methanol*solution-1mg per M
D-AMPHETAMINE SULFATE METHANOLSOLUTION-1 MG PER ML
Benzeneethanamine,.alpha.-methyl-,(S)-,sulfate(2:1)
alpha-methyl-benzeneethanamin(s)-benzeneethanaminsulfate(2:1)
Benzeneethanamine, .alpha.-methyl-, (.alpha.S)-, sulfate (2:1)
(+)-α-Methylphenethylamine sulfate salt, Dextroamphetamine sulfate salt | [EINECS(EC#)]
200-111-6 | [Molecular Formula]
C18H28N2O4S | [MDL Number]
MFCD00069209 | [MOL File]
51-63-8.mol | [Molecular Weight]
368.49 |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
>300° | [alpha ]
D20 +21.8° (c = 2) | [density ]
1.1500 | [refractive index ]
1.6930 (estimate) | [storage temp. ]
Desiccate at RT | [solubility ]
H2O: soluble
| [form ]
Powder | [color ]
Plates | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble to 100 mM in water | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)/t2*8-;/m00./s1 | [InChIKey]
PYHRZPFZZDCOPH-QXGOIDDHSA-N | [SMILES]
OS(O)(=O)=O.CC(N)Cc1ccccc1.CC(N)Cc2ccccc2 | [Uses]
Amfetamine | [EPA Substance Registry System]
Benzeneethanamine, .alpha.-methyl-, (.alpha.S)-, sulfate (2:1) (51-63-8) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Biological Activity]
CNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. | [Originator]
Dexedrine Sulfate,SKF,US,1944 | [Manufacturing Process]
Two mols, for example, 270 grams, of racemic α-methylphenethylamine base
are reacted with one mol (150 grams) of d-tartaric acid, thereby forming dl-αmethylphenethylamine d-tartrate, a neutral salt. The neutral salt thus
obtained is fully dissolved by the addition of sufficient, say about 1 liter, of
absolute ethanol, and heating to about the boiling point. The solution is then
allowed to cool to room temperature with occasional stirring to effect
crystallization. The crystals are filtered off and will be found to contain a
preponderance of the levo enantiomorph.
The residual solid in the mother liquors is repeatedly and systematically
crystallized, yielding a further fraction of 1-α-methylphenethylamine d-tartrate
which may be purified by recrystallization. d-α-Methylphenethylamine may be
readily recovered from the mother liquors by the addition of tartaric acid
thereto for the formation of acid tartrates and separation of d-αmethylphenethylamine d-bitartrate by crystallization.
The free base of either optical isomer may be obtained by addition to the dtartrate in the case of the levo isomer and the d-bitartrate in the case of the
dextro isomer of alkali in excess, as, for example, by the addition of an
aqueous solution of caustic soda, which will cause the base to separate as an oil which may be recovered and purified by any well-known procedure. The
base is exactly neutralized with sulfuric acid to give the sulfate. | [Therapeutic Function]
Central stimulant | [storage]
Desiccate at RT |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H300 | [Precautionary statements ]
P264-P270-P301+P310-P321-P330-P405-P501 | [Hazard Codes ]
T,F | [Risk Statements ]
25-39/23/24/25-23/24/25-11 | [Safety Statements ]
45-36/37-16 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
SI1400000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2921460000 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral | [Safety Profile]
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. A human teratogen that
causes developmental abnormalities of the
central nervous system. Experimental
reproductive effects including other
teratogenic effects. A habit-forming
stimulant. When heated to decomposition it
emits very toxic fumes of SO, and NO,. See
also other benzidrine compounds and
SULFATES. | [Toxicity]
LD50 orally in mice: 10 mg/kg (Warawa) |
|
|