| Identification | Back Directory | [Name]
3-(4-Hydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one | [CAS]
51225-30-0 | [Synonyms]
Wighteone
Erythrinin B
5,7,4'-Trihydroxy-6-prenylisoflavone
4',5,7-Trihydroxy-6-prenyl-isoflavone
4',5,7-Trihydroxy-6-(3-methyl-2-butenyl)isoflavone
5,7-dihydroxy-3-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-1-benzopyran-4-one
3-(4-Hydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C20H18O5 | [MDL Number]
MFCD06796682 | [MOL File]
51225-30-0.mol | [Molecular Weight]
338.35 |
| Chemical Properties | Back Directory | [Melting point ]
227 °C(Solv: methanol (67-56-1)) | [Boiling point ]
586.1±50.0 °C(Predicted) | [density ]
1.351±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.03±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Wighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol. | [Definition]
ChEBI: A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 6. It has been isolated from Ficus mucuso. | [target]
HSP (e.g. HSP90) | Antifection |
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