| Identification | Back Directory | [Name]
3,4-dihydroxy-Butanoic acid | [CAS]
51267-44-8 | [Synonyms]
3,4-dihydroxy-Butanoic acid
(S)-3,4-Dihydroxybutyric acid
(3S)-3,4-Dihydroxybutanoic acid
Butanoic acid, 3,4-dihydroxy-, (3S)- | [Molecular Formula]
C4H8O4 | [MDL Number]
MFCD19228116 | [MOL File]
51267-44-8.mol | [Molecular Weight]
120.1 |
| Chemical Properties | Back Directory | [Boiling point ]
408.9±35.0 °C(Predicted) | [density ]
1.420±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
solid | [pka]
4.27±0.10(Predicted) | [optical activity]
[α]/D -25±5°, 24hr, c =0.1 in 0.1 M HCl |
| Hazard Information | Back Directory | [Uses]
(S)-3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency. | [Definition]
ChEBI: 3S,4-dihydroxy-butyric acid is a 3-hydroxy carboxylic acid. | [Biological Activity]
3,4-Dihydroxybutyric acid is a normal human urinary metabolite th at is excreted in increased concentration in patients with succinic semialdehyde dehydro- genase (SSADH) deficiencywhile healthy adults excrete 0.37 +/- 0.15 (SD) mmoles of 3,4- dihydroxybutyrate per 24 hr. The renal clearance of this compound is roughly equal th at of creatinine. This metabolite is also detectable in blood. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Shinka T, et al. Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency. J Chromatogr B Analyt Technol Biomed Life S DOI:10.1016/s1570-0232(02)00126-5 |
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