| Identification | Back Directory | [Name]
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester | [CAS]
512840-45-8 | [Synonyms]
MS438
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester | [Molecular Formula]
C20H17F3N2O3 | [MDL Number]
MFCD02972687 | [MOL File]
512840-45-8.mol | [Molecular Weight]
390.36 |
| Chemical Properties | Back Directory | [Boiling point ]
481.6±45.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.85±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MS438 is a potent agonist of the TSH receptor (TSHR). | [Uses]
MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice[1]. | [References]
[1] Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25(1):51-62. DOI:10.1089/thy.2014.0119 |
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