| Identification | Back Directory | [Name]
THIODIGALACTOSIDE | [CAS]
51555-87-4 | [Synonyms]
TDG
THIODIGALACTOSIDE
Galactosyl 1-thiogalactoside
d-galactopyranosyl-β-d-thiogalactopyranoside
D-Galactopyranosyl-b-D-thiogalactopyranoside
D-GALACTOPYRANOSYL BETA-D-THIOGALACTOPYRANOSIDE
D-Galactopyranosyl-β-D-thiogalactopyranoside ,98%
β-D-Galactopyranoside, β-D-galactopyranosyl 1-thio- | [Molecular Formula]
C12H22O10S | [MDL Number]
MFCD00057491 | [MOL File]
51555-87-4.mol | [Molecular Weight]
358.36 |
| Chemical Properties | Back Directory | [Melting point ]
>225°C (dec.) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly) | [form ]
Solid | [color ]
White | [Water Solubility ]
H2O: 2mg/mL, clear | [InChI]
InChI=1/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12?/s3 | [InChIKey]
SYKYBMOFPMXDRQ-YSLNCGCNNA-N | [SMILES]
C1([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O)S[C@H]1[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O |&1:1,3,4,6,12,13,15,16,18,r| |
| Hazard Information | Back Directory | [Description]
Galectins are a family of glycan-binding lectins with diverse regulatory roles in physiological processes. They have significant roles in inflammation and cancer. Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 μM. It is used to investigate the roles of these galectins in cell signaling and carcinogenesis. | [Chemical Properties]
White to off-white crystalline powder | [Uses]
Thiogdigalactosideis an inhibitor of galectin 1 which has an essential role in high-fat diet induced obesity development. | [storage]
Store at -20°C | [References]
[1] ALI HASAN EBRAHIM. Galectins in cancer: carcinogenesis, diagnosis and therapy.[J]. Annals of translational medicine, 2014, 2 9: 88. DOI: 10.3978/j.issn.2305-5839.2014.09.12
[2] NANDOR GABOR THAN. Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia.[J]. Journal of Pathology and Translational Medicine, 2015, 49 3: 181-208. DOI: 10.4132/jptm.2015.02.25
[3] BADER A. SALAMEH . 1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2010, 18 14: Pages 5367-5378. DOI: 10.1016/j.bmc.2010.05.040
[4] HILDE VAN HATTUM. Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1[J]. Journal of Medicinal Chemistry, 2013, 56 3: 1350-1354. DOI: 10.1021/jm301677r
[5] KOICHI ITO. Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress[J]. Angiogenesis, 2011, 14 3: 293-307. DOI: 10.1007/s10456-011-9213-5
[6] PEIWEN KUO. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response.[J]. Clinical Cancer Research, 2014, 20 21: 5558-5569. DOI: 10.1158/1078-0432.ccr-14-1138
[7] R MUKHERJEE. Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[J]. International Journal of Obesity, 2015, 39 9: 1349-1358. DOI: 10.1038/ijo.2015.74 |
|
| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Website: |
https://www.alfa-chemistry.com |
|