| Identification | Back Directory | [Name]
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine | [CAS]
515880-75-8 | [Synonyms]
DMH-4
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine
Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl- | [Molecular Formula]
C24H24N4O2 | [MDL Number]
MFCD18452839 | [MOL File]
515880-75-8.mol | [Molecular Weight]
400.47 |
| Chemical Properties | Back Directory | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL | [form ]
powder | [pka]
6.28±0.10(Predicted) | [color ]
off-white to brown |
| Hazard Information | Back Directory | [Description]
DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 μM in a cell-free assay) and a derivative of dorsomorphin . It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 μM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 μM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM). | [Uses]
DMH 4 is a selective VEGFR-2 inhibitor. DMH 4 displays antiangiogenic activity in vitro and in vivo. | [IC 50]
VEGFR2: 0.16 μM (IC50) | [storage]
Store at -20°C | [References]
[1] JIJUN HAO. In Vivo Structure?Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors[J]. ACS Chemical Biology, 2009, 5 2: 245-253. DOI: 10.1021/cb9002865
[2] HAO LI . DMH4, a VEGFR2 inhibitor, effectively suppresses growth and invasion of lung cancer cells[J]. Journal of applied biomedicine, 2018, 16 1: Pages 46-50. DOI: 10.1016/j.jab.2017.10.006 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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