| Identification | Back Directory | [Name]
2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid | [CAS]
516-90-5 | [Synonyms]
Lithocholyltaurine
Taurolithocholic Acid D8
Taurodeoxycholic Acid Impurity 3
Lithocholic acid taurine conjugate
Taurolithocholic Acid MaxSpec? Standard
N-(3α-Hydroxy-24-oxo-5β-cholan-24-yl)taurine
2-[(3α-Hydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid
Ethanesulfonic acid, 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-
Taurolithocholic acidQ: What is
Taurolithocholic acid Q: What is the CAS Number of
Taurolithocholic acid
2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid | [Molecular Formula]
C26H45NO5S | [MDL Number]
MFCD00200615 | [MOL File]
516-90-5.mol | [Molecular Weight]
483.7 |
| Chemical Properties | Back Directory | [Melting point ]
212-213 °C | [density ]
1.0476 (rough estimate) | [refractive index ]
1.5650 (estimate) | [storage temp. ]
-20°C | [form ]
powder | [pka]
1.42±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cell cycle, and promoting DNA synthesis in a concentration-dependent manner in the intrahepatic cholangiocarcinoma cell line RMCCA-1. It can also increase the phosphorylation of EGFR and ERK 1/2 and the expression of cyclin D1 in RMCCA-1 cells, and its induced RMCCA-1 cell growth can be inhibited by specific antagonists and inhibitors. | [Definition]
ChEBI: Taurolithocholic acid is the bile acid taurine conjugate of lithocholic acid. It has a role as a human metabolite. It is a monocarboxylic acid amide and a bile acid taurine conjugate. It is functionally related to a lithocholic acid. It is a conjugate acid of a taurolithocholate. | [IC 50]
Human Endogenous Metabolite | [storage]
-20°C | [References]
[1] High Frequency Technique for Continuous Recording in Chromatographic Analysis of Bile Acids |
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