51788-80-8

1481-27-2

74-88-4

51788-80-8

4-Fluoro-2-hydroxyacetophenone (12.0 g, 77.9 mmol) was reacted with iodomethane (6.38 ml, 101 mmol) and potassium carbonate (14.0 g, 101 mmol) in acetonitrile (200 ml) at 75 °C for 8 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and concentrated under reduced pressure to remove the solvent. To the residue was added fresh acetonitrile (150 ml), iodomethane (2 ml, 32 mmol) and potassium carbonate (4 g, 29 mmol) and the reaction was continued at 75°C for 3 hours. The reaction mixture was concentrated, diluted by adding ethyl acetate (100 ml), filtered and the solvent was evaporated under reduced pressure to give 4-fluoro-2-methoxyacetophenone (13.5 g, 100% yield). Mass spectral data: m/z 168 (M+, 11), 153 (base peak), 110 (23), 95 (21), 82 (12).