| Identification | Back Directory | [Name]
Dehydroglyasperin D | [CAS]
517885-72-2 | [Synonyms]
Dehydroglyasperin D
1,3-Benzenediol, 4-[5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]- | [Molecular Formula]
C22H24O5 | [MDL Number]
MFCD28100620 | [MOL File]
517885-72-2.mol | [Molecular Weight]
368.42 |
| Hazard Information | Back Directory | [Uses]
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3]. | [References]
[1] Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33(5):917-21. DOI:10.1248/bpb.33.917
[2] Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19(1):135-42. DOI:10.1111/jcmm.12311
[3] Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32(8):982-988. DOI:10.4014/jmb.2207.07043 |
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