| Identification | Back Directory | [Name]
Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH | [CAS]
51833-69-3 | [Synonyms]
SAR-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH
Angiotensin II, 1-(N-methylglycine)-5-L-isoleucine- | [Molecular Formula]
C49H71N13O10 | [MDL Number]
MFCD00167493 | [MOL File]
51833-69-3.mol | [Molecular Weight]
1002.17 |
| Hazard Information | Back Directory | [Uses]
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3]. | [IC 50]
AT1 Receptor | [References]
[1] Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38(23):4660-9. DOI:10.1021/jm00023a005
[2] Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258(3 Pt 2):H806-13. DOI:10.1152/ajpheart.1990.258.3.H806
[3] Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11(2):243-53. DOI:10.1016/0196-9781(90)90077-i |
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