| Identification | More | [Name]
S-NITROSOGLUTATHIONE | [CAS]
57564-91-7 | [Synonyms]
GNSO
GSNO
N-(N-L-GAMMA-GLUTAMYL-S-NITROSO-L-CYSTEINYL)-GLYCINE
S-NITROSOGLUTATHIONE
S-NITROSO-L-GLUTATHIONE
SNOG
n-(n-l-gamma-glutamyl-2-nitroso-l-cysteinyl)-glycin
nitrosoglutathione
N-(N-L-g-Glutamyl-S-nitroso-L-cysteinyl)glycine
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
N-(N-L-GAMMA-GLUTAMYL-S-NITROSO-L-CYSTEINYL)GLYCINE (S-NITROSOGLUTATHIONE)
GSNO, SNOG
S-NITROSO-L-GLUTATHIONE, 97+%
L-γGlu-S-Nitroso-L-Cys-Gly-OH
γGlu-S-Nitroso-Cys-Gly-OH | [EINECS(EC#)]
248-170-7 | [Molecular Formula]
C10H16N4O7S | [MDL Number]
MFCD00214341 | [Molecular Weight]
336.32 | [MOL File]
57564-91-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Pink Powder | [Melting point ]
>170°C (dec.) | [density ]
1.68 | [refractive index ]
1.6000 (estimate) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Pink solid | [pka]
2.21±0.10(Predicted) | [color ]
Off-White to Pink | [Water Solubility ]
Soluble to 100 mM in water | [Usage]
A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation | [Stability:]
Hygroscopic | [InChI]
InChI=1/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/s3 | [InChIKey]
HYHSBSXUHZOYLX-FJGCHTOXNA-N | [SMILES]
[C@@H](CSN=O)(NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O |&1:0,10,r| | [CAS DataBase Reference]
57564-91-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
MC0558000
|
| Hazard Information | Back Directory | [Description]
S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.1,2,3,4 | [Chemical Properties]
Pink Powder | [Uses]
S-Nitrosoglutathione (GSNO) has been used:
- as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
- as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.
| [Uses]
A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation | [Definition]
ChEBI: S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a platelet aggregation inhibitor, a bronchodilator agent, a nitric oxide donor and a signalling molecule. It is a glutathione derivative and a nitrosothio compound. It is a conjugate acid of a S-nitrosoglutathione(2-). | [General Description]
A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg. | [Biological Activity]
A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation. | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
Desiccate at -20°C | [References]
[1] MAREK W. RADOMSKI. S-nitroso-glutathione inhibits platelet activation in vitro and in vivo[J]. British Journal of Pharmacology, 1992, 107 3: 745-749. DOI: 10.1111/j.1476-5381.1992.tb14517.x
[2] ANTHONY R. ANTHONY Peter R. Chemistry, Analysis, and Biological Roles ofS-Nitrosothiols[J]. Analytical biochemistry, 1997, 249 1: Pages 1-9. DOI: 10.1006/abio.1997.2129
[3] A GASCO G S R Fruttero. No-donors: an emerging class of compounds in medicinal chemistry.[J]. Farmaco (Societa chimica italiana?: 1989), 1996, 51 10: 617-635.
[4] JOHN A. COOK . Convenient Colorimetric and Fluorometric Assays for S-Nitrosothiols[J]. Analytical biochemistry, 1996, 238 2: Pages 150-158. DOI: 10.1006/abio.1996.0268 |
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Rhawn Reagent Gold
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400-1332688 18019345275 |
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https://www.rhawn.cn/ |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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