| Identification | Back Directory | [Name]
Pizotifen Malate | [CAS]
5189-11-7 | [Synonyms]
mosegor
sanomtgran
bc105malate
litecmalate
malate(1:1)
Pizotifen Mala
PIZOTIFEN MALATE
Einecs 225-970-4
sandomygranmalate
PIZOTYLINE MALATE
sandomigranmalate
pizotifenhydrogenmalate
Pizotifen Malate USP/EP/BP
Benzene thiamethoxam organism malate
9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate
9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate (1:1)
Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-B)thien-4-ylidene)-1-methyl-, malate (1:1)
4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidinium hydrogen malate
Malic acid, coMpound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-Methylpiperidine
4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID
malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1)
Butanedioicacid, 2-hydroxy-, coMpd. with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-Methylpiperidine(1:1) | [EINECS(EC#)]
225-970-4 | [Molecular Formula]
C23H27NO5S | [MDL Number]
MFCD01700978 | [MOL File]
5189-11-7.mol | [Molecular Weight]
429.53 |
| Chemical Properties | Back Directory | [Melting point ]
185-186° (dec) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Aqueous Acid (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [Major Application]
pharmaceutical
pharmaceutical small molecule | [InChI]
1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9) | [InChIKey]
IWAWCPZVTXCFKD-UHFFFAOYSA-N | [SMILES]
[s]1c2c(cc1)C(=C4CCN(CC4)C)c3c(cccc3)CC2.OC(CC(=O)O)C(=O)O |
| Hazard Information | Back Directory | [Uses]
Antimigraine | [Uses]
Pizotifen, C19H21NS· C4H6O5, is piperidine derivatives. Though antihistamines, it is mainly used because of their antiserotonergic properties. | [Definition]
ChEBI: A malate salt resulting from the reaction of equimolar amounts of pizotifen and malic acid. A sedating antihistamine with strong serotonin antagonist and weak antimuscarinic activity, it is used for the treatment of migraine and the prevention of headache
ttacks during cluster periods. | [in vivo]
The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group[3]. | [IC 50]
5-HT2A Receptor; 5-HT1C Receptor |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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