51951-05-4

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51951-05-4 Structure

Identification	Back Directory
[Name] HO-PEG3-CH2COOH
[CAS] 51951-05-4
[Synonyms] 51951-05-4 PEG3-O-CH2COOH PROTAC Linker 8 HO-PEG3-CH2COOH triethylene glycol monoglycolide 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetic acid Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-
[Molecular Formula] C8H16O6
[MDL Number] MFCD24479936
[MOL File] 51951-05-4.mol
[Molecular Weight] 208.21

Chemical Properties	Back Directory
[Boiling point ] 375.2±27.0 °C(Predicted)
[density ] 1.211±0.06 g/cm3(Predicted)
[form ] Viscous Liquid
[pka] 3.39±0.10(Predicted)
[color ] Colorless to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H315-H319-H335
[Precautionary statements ] P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Hazard Information	Back Directory
[Uses] PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs[1].
[IC 50] PEGs
[References] [1] Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. DOI:10.1074/jbc.M116.768853

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