| Identification | Back Directory | [Name]
HO-PEG5-CH2COOtBu | [CAS]
52026-48-9 | [Synonyms]
HO-PEG5-CH2COOH
HO-PEG5-CH2COOtBu
Hydroxy-PEG5-CH2COOH
Hydroxy-PEG5-acetic acid | [Molecular Formula]
C12H24O8 | [MDL Number]
MFCD31656910 | [MOL File]
52026-48-9.mol | [Molecular Weight]
296.31 |
| Chemical Properties | Back Directory | [Boiling point ]
444.5±40.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [pka]
3.39±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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