| Identification | Back Directory | [Name]
Pygenic acid A | [CAS]
52213-27-1 | [Synonyms]
Pygenic acid A
PUNICALAGINS A&B(P)
3-Epicorosolic acid
2,3-Dihydroxy-12-ursen-28-oic acid
(2alpha,3alpha)-2,3-Dihydroxy-urs-12-en-28-oic acid
2α,3α-Dihydroxy-19β-methyl-30-noroleana-12-ene-28-oic acid | [Molecular Formula]
C30H48O4 | [MOL File]
52213-27-1.mol | [Molecular Weight]
472.7 |
| Hazard Information | Back Directory | [Description]
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction.
3-Epicorosolic acid shows both potent α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively.
3. 3-Epicorosolic acid shows mixed type inhibition against PTP1B, while it shows uncompetitive inhibition against α-glucosidase; suggests that it has potential antidiabetic activity.
4. 3-Epicorosolic acid possesses the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, it has potential anti-inflammatory activities as well as cancer chemopreventive activity. | [Uses]
Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers[1]. | [target]
Immunology & Inflammation related | [References]
[1] Ga-Eun Lim, et al. Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo. Int J Mol Sci. 2020 Nov; 21(22): 8444. DOI:10.3390/ijms21228444 |
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| Company Name: |
BioBioPha Co., Ltd.
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| Tel: |
0871-65217109 13211707573; |
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http://www.biobiopha.com |
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