| Identification | Back Directory | [Name]
Iturin A | [CAS]
52229-90-0 | [Synonyms]
Eumycin
Bacillomycin B
Bacillomycin R | [Molecular Formula]
C37H51N12O14R | [MDL Number]
MFCD01094135 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
ethanol: soluble9.80 - 10.20 mg/mL | [form ]
Solid | [color ]
White to off-white | [Sequence]
cyclo[D-Asn-Gln-Pro-D-Asn-Ser-Unk-Asn-D-Tyr] |
| Hazard Information | Back Directory | [Uses]
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity[1][2]. | [in vivo]
Iturin A (3 mg/kg; 15 days) has antitumor activity in a mouse model of liver cancer[2]. | Animal Model: | HepG2 cells treated female BALB/c nude mice aged 4 weeks old[2] | | Dosage: | 3 mg/kg | | Administration: | 15 days | | Result: | Significantly inhibited tumor growth.
Induced apoptosis and autophagy of tumor cells.
Improved the tumor immune microenvironment.
Had no significant influence on body weight, food intake, and viscera index in mice
Interfered with the liver function of mice, but has no significant effect on the renal function.
Was safe to kidney and spleen.
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| [References]
[1] Gong AD, et al. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS One. 2015 Feb 17;10(2):e0116871. DOI:10.1371/journal.pone.0116871
[2] Zhao H, et al. Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo. AMB Express. 2021 May 10;11(1):67. DOI:10.1186/s13568-021-01226-4 |
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