| Identification | Back Directory | [Name]
Nsc264136 | [CAS]
52238-35-4 | [Synonyms]
Nsc264136
9-hydroxyellipticine HCl salt
9-Hydroxyellipticine, Hydrochloride | [Molecular Formula]
C17H15ClN2O | [MDL Number]
MFCD02683589 | [MOL File]
52238-35-4.mol | [Molecular Weight]
298.767 |
| Chemical Properties | Back Directory | [Melting point ]
>223oC (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
Orange to Dark Orange |
| Hazard Information | Back Directory | [Description]
9-Hydroxyellipticine is a derivative of ellipticine with diverse biological activities. It inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively). 9-Hydroxyellipticine inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model. It inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs. | [Uses]
9-Hydroxyellipticine Hydrochloride is a potent topoisomerase II inhibitor. | [in vivo]
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1].
| Animal Model: | Three- to five-month-old C57B1/6 male mice[1]. | | Dosage: | 5 or 10 mg/kg. | | Administration: | IP. | | Result: | Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells. |
| [IC 50]
Topoisomerase II | [References]
[1] PIERRE LESCA . A class of strong inhibitors of microsomal monooxygenases: The elupticines[J]. Chemico-Biological Interactions, 1979, 24 2: Pages 189-197. DOI: 10.1016/0009-2797(79)90007-3
[2] M MONNOT. DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivatives.[J]. The Journal of Biological Chemistry, 1991, 266 3: 1820-1829.
[3] J B LE PECQ. Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection.[J]. Cancer research, 1976, 36 9 pt.1: 3067-3076.
[4] J CROS N D X A Thibault. [Anti-inflammatory effect of hydroxy-9-ellipticine].[J]. Comptes rendus hebdomadaires des seances de l’Academie des sciences. Serie D: Sciences naturelles, 1975, 281 15: 1139-1142.
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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