52386-42-2

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52386-42-2 Structure

Identification	Back Directory
[Name] Ketotrexate
[CAS] 52386-42-2
[Synonyms] NSC139490 NSC-139490 NSC 139490 Emofolin sodium MeTHHF disodium
[Molecular Formula] C21H28N7NaO6
[MOL File] 52386-42-2.mol
[Molecular Weight] 497.49

Hazard Information	Back Directory
[Uses] Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases[1][2].
[References] [1] Puig L. Methotrexate: new therapeutic approaches. Actas Dermosifiliogr. 2014 Jul-Aug;105(6):583-9. DOI:10.1016/j.ad.2012.11.017 [2] Torres RP, et al. Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis. ARP Rheumatol. 2022 Oct 1;1(3):225-229. PMID:35724450

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