| Identification | Back Directory | [Name]
LHRH (1-5) | [CAS]
52434-75-0 | [Synonyms]
LHRH (1-5)
PGLU-HIS-TRP-SER-TYR
LHRH (1-5), free acid
Goserelin Impurity 13
PYR-HIS-TRP-SER-TYR-OH
Goserelin EP Impurity 13
Goserelin Impurity 26 Acetate
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine
L-Tyrosine, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl- | [Molecular Formula]
C34H38N8O9 | [MDL Number]
MFCD00153559 | [MOL File]
52434-75-0.mol | [Molecular Weight]
702.71 |
| Hazard Information | Back Directory | [Uses]
LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983)[1][2]. | [References]
[1] McDermott JR, et al. Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. Peptides. 1983 Jan-Feb;4(1):25-30. DOI:10.1016/0196-9781(83)90160-2
[2] Yokosawa H, et al. Degradation of luteinizing hormone-releasing hormone by neuroblastoma cells and their membrane: evidence for the involvement of a thiol protease and angiotensin-converting enzyme. J Neurochem. 1987 Jan;48(1):293-8. DOI:10.1111/j.1471-4159.1987.tb13161.x |
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