| Identification | Back Directory | [Name]
JNJ-10229570 | [CAS]
524923-88-4 | [Synonyms]
JNJ-10229570
JNJ-10229571
UNII-N9IX402L35
JNJ-10229570; JNJ10229570; JNJ 10229570
Benzenamine, N-[2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]- | [Molecular Formula]
C22H19N3O2S | [MDL Number]
MFCD31807596 | [MOL File]
524923-88-4.mol | [Molecular Weight]
389.47 |
| Chemical Properties | Back Directory | [Boiling point ]
541.2±60.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 62.5 mg/mL (160.47 mM) | [form ]
Solid | [pka]
0.95±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively. | [in vivo]
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice result in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA). Topical treatment with 0.05% JNJ-10229570 leads to a distinct reduction in both the steady-state and the newly-synthesized sebum-specific lipids, with lesser effects on triglycerides and cholesterol[1]. | [storage]
Store at -20°C | [References]
[1] Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. DOI:10.1016/j.jdermsci.2011.04.001 |
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