| Identification | Back Directory | [Name]
4(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridine hydrochloride | [CAS]
52669-92-8 | [Synonyms]
HPTP
HLPR
HPTPA
RPTPA
PTPRS
R-PTP-α
Dehydrated Haloperidol
Haloperidol Impurity 43
PTPsigma/PTPRS Active human
PTPRA (174-802), active, GST tagged human
Haloperidol Impurity 9（Dehydrate Haloperidol）
Protein tyrosine phosphatase, receptor type, S
1-[4-Oxo-4-(4-fluorophenyl)butyl]-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine
4-[4-(4-Chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-1-butanone
4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-1-(4-fluorophenyl)butan-1-one
1-Butanone, 4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-
4-[[4-(4-Chlorophenyl)-1,2,3,6-tetrahydropyridin]-1-yl]-1-(4-fluorophenyl)-1-butanone
4(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridine hydrochloride | [Molecular Formula]
C21H21ClFNO | [MDL Number]
MFCD28252198 | [MOL File]
52669-92-8.mol | [Molecular Weight]
357.85 |
| Chemical Properties | Back Directory | [Melting point ]
97 - 100°C | [density ]
1.196 | [storage temp. ]
-70°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
aqueous solution | [color ]
Pale Yellow | [biological source]
human | [Specific Activity]
1799-2435nmol/min·mg |
| Hazard Information | Back Directory | [Uses]
4-[4-(4-Chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-1-butanone is a dehydrated metabolite of haloperidol that can be biotransfomed by humans to Haloperidol pyridinium (HPP+), a potential neurotoxic found in the brain. | [Definition]
ChEBI: 4-(4-(P-Chlorophenyl)-2,5,6-Trihydropyridino)-4'-Fluorobutyrophenone is an aromatic ketone. | [Biological Activity]
Protein tyrosine phosphatasereceptor type S (PTPRS)/ PTPs localized on the cell surface plays a vital role in cell–cell and cell– extracellular matrix (ECM) interactionsand is implicated in the regulation of axon homeostasis and neuronal development. In additionPTPRS also has a crucial role in autophagy regulation. PTPRS expressed on plasmacytoid dendritic cells (pDCs) inhibits the production of type I interferon (IFN) in response to viruses. Mutation of both Ptprs and Ptprf (protein tyrosine phosphatasereceptor type F) results in pDC hyperactivation and mild colitis. |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
NE Scientific
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+1 (617) 651-6662 |
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www.chemicalbook.com/ShowSupplierProductsList19253/0_EN.htm |
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