| Identification | Back Directory | [Name]
(R)-5,7-Dihydroxyspiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one | [CAS]
52706-07-7 | [Synonyms]
Scylin
Scillascillin
(R)-5,7-Dihydroxyspiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one
Spiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one, 5,7-dihydroxy-, (3R)- | [Molecular Formula]
C17H12O6 | [MDL Number]
MFCD20260990 | [MOL File]
52706-07-7.mol | [Molecular Weight]
312.27 |
| Hazard Information | Back Directory | [Uses]
Scillascillin (compound 10) is a homoisoflavanone. Scillascillin can be isolated from S. scilloides. Scillascillin shows anticancer activity towards MCF-7 (breast cancer) and DU-145 (prostate cancer) cells with the IC50 of 9.59 and 11.32 ug/ml, respectively[1][2]. | [Synthesis]
The dried whole herb powder of Mianzhaoer was extracted with 95% industrial ethanol for three times at room temperature for 3 d each time, and about 1,936 g of extract was obtained, which was separated by silica gel column chromatography, and 10 fragments | [References]
[1] Yoichiro Nishida, et al. A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides. Chem Pharm Bull (Tokyo). 56, 7. DOI:10.1248/cpb.56.1022
[2] Chinthala Y, et al. Anticancer Active Homoisoflavone from the Underground Bulbs of Ledebouria hyderabadensis. Pharmacognosy Res. 2014;6(4):303-305. DOI:10.4103/0974-8490.138272 |
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