| Identification | Back Directory | [Name]
Imidazo[2,1-b]thiazole-5-sulfonamide, 6-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]- | [CAS]
528859-04-3 | [Synonyms]
E6801
E-6801
E 6801
Imidazo[2,1-b]thiazole-5-sulfonamide, 6-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]- | [Molecular Formula]
C17H18ClN5O2S2 | [MOL File]
528859-04-3.mol | [Molecular Weight]
423.94 |
| Hazard Information | Back Directory | [Uses]
E6801 is a 5-HT6 receptor agonist that improves recognition memory by jointly modulating cholinergic and glutamatergic neurotransmission. E6801 can be used in studies of dementia, depression, obesity, epilepsy, etc[1]. | [in vivo]
E6801 (1.25-10 mg/kg, i.p.) can reverse Scopolamine (HY-N0296)-induced memory impairment in rats[1]. | [IC 50]
5-HT6 Receptor | [References]
[1] Kendall I,et al. E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat. Psychopharmacology (Berl). 2011 Feb;213(2-3):413-30. DOI:10.1007/s00213-010-1854-3 |
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