| Hazard Information | Back Directory | [Description]
PKF050-638 is a HIV-1 Rev inhibitor. It acts by interfering with the CRM1-mediated nuclear export and specifically inhibiting Rev-dependent luciferase reporter gene expression. | [Uses]
PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction[1]. | [References]
[1] Daelemans D, et al. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proc Natl Acad Sci U S A.?2002?Oct 29;99(22):14440-5. Epub?2002?Oct 9. DOI:10.1073/pnas.212285299 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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