| Identification | Back Directory | [Name]
3,6-DIHYDROXYXANTHONE | [CAS]
529-61-3 | [Synonyms]
Eyxanthone
IFLAB-BB F0349-4255
3,6-DIHYDROXYXANTHONE
1,7-DIHYDROXYXANTHONE
1,7-Dihydroxy-9H-xanthen-9-one
9H-Xanthen-9-one, 1,7-dihydroxy- | [Molecular Formula]
C13H8O4 | [MDL Number]
MFCD00914848 | [MOL File]
529-61-3.mol | [Molecular Weight]
228.2 |
| Hazard Information | Back Directory | [Uses]
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. | [Definition]
ChEBI: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense. | [Synthesis Reference(s)]
Synthetic Communications, 19, p. 1641, 1989 DOI: 10.1080/00397918908051061 | [in vivo]
Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2]. | Animal Model: | Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] | | Dosage: | 30 mg/kg, 60 mg/kg | | Administration: | p.o.;once a day; for 7 days | | Result: | Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
| [References]
[1] Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. DOI:10.1002/ar.23992
[2] Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. DOI:10.5114/ceji.2021.111444
[3] aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. DOI:10.1007/s12031-018-1175-2 |
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