| Identification | Back Directory | [Name]
6-CHLORO-1H-INDOLE-2-CARBALDEHYDE | [CAS]
53590-59-3 | [Synonyms]
6-CHLORO-1H-INDOLE-2-CARBALDEHYDE
1H-Indole-2-carboxaldehyde, 6-chloro- | [Molecular Formula]
C9H6ClNO | [MDL Number]
MFCD11040767 | [MOL File]
53590-59-3.mol | [Molecular Weight]
179.6 |
| Chemical Properties | Back Directory | [Boiling point ]
373.4±22.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
14.15±0.30(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Synthesis]
GENERAL STEPS: A suspension of 2-hydroxymethyl-6-chloroindole (1 mmol) with activated MnO2 (10 mmol) in DMF (30 mL) was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated under vacuum and the residue was purified by column chromatography to afford 6-chloro-1H-indole-2-carbaldehyde using EtOAc-hexane mixed solvent as eluent. | [References]
[1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577
[2] Patent: US2003/144282, 2003, A1
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1380 - 1400
[4] Patent: US2008/9485, 2008, A1. Location in patent: Page/Page column 31
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 2, p. 364 - 377 |
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