| Identification | More | [Name]
6-Chloroindole-2-carboxylic acid ethyl ester | [CAS]
27034-51-1 | [Synonyms]
6-CHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
SPECS AP-283/40634148
6-Chloroindole-2-Carboxylic Acid Ethyl Acid
Ethyl 6-chloroindole-2-carboxylate
6-CHLORO-2-INDOLECARBOXYLIC METHYL ESTER
Ethyl 6-Chloroindole-2-Carboxylicate
6-CHLORO-2-INDOLECARBOXYLIC
6-Chloroindole-2-carboxylic acid ethyl ester ,99% | [Molecular Formula]
C11H10ClNO2 | [MDL Number]
MFCD03084731 | [Molecular Weight]
223.66 | [MOL File]
27034-51-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
169-171 °C | [Boiling point ]
375.0±22.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
14.11±0.30(Predicted) | [Appearance]
Light brown to gray Solid | [Detection Methods]
HPLC | [CAS DataBase Reference]
27034-51-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Ethyl 6-chloroindole-2-carboxylate is an organic compound mainly used as a pharmaceutical intermediate and chemical reagent. | [Synthesis]
General method: 6a-d (9.2 mmol) was dissolved in toluene (150 mL) under nitrogen protection, rhodium(II) acetate dimer (203 mg, 0.46 mmol) was added, and the reaction was heated to reflux for 1-2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 25:1 to 18:1, v/v) to afford the target product ethyl 6-chloroindole-2-carboxylate (7a-d) in 51.7%-58.6% overall yields. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1760 - 1762
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 4, p. 1283 - 1292 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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