| Identification | Back Directory | [Name]
1-Hydroxyrutaecarpine | [CAS]
53600-24-1 | [Synonyms]
1-Hydroxyrutaecarpine
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-1-hydroxy- | [Molecular Formula]
C18H13N3O2 | [MDL Number]
MFCD20260539 | [MOL File]
53600-24-1.mol | [Molecular Weight]
303.31 |
| Chemical Properties | Back Directory | [Boiling point ]
601.7±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
8.80±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 μg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3]. | [References]
[1] Bruno Danieli; et al. 1-Hydroxyrutaecarpine from Euxylophora para?nsis. Phytochemistry, 1974 , 13(8), 1603–1606.
[2] Chen JJ, et al. New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. Planta Med. 2005 May;71(5):470-5. DOI:10.1055/s-2005-864144
[3] Sheen WS, et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Planta Med. 1996 Apr;62(2):175-6. DOI:10.1055/s-2006-957846 |
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