| Identification | More | [Name]
4-Ethylphenylhydrazine hydrochloride | [CAS]
53661-18-0 | [Synonyms]
1-(4-ETHYLPHENYL)HYDRAZINE HYDROCHLORIDE
3-BROMO-4-AMINOPYRIDINE
3-BROMO-4-PYRIDINAMINE
3-BROMO-4-PYRIDINEAMINE
3-BROMO-4-PYRIDINYLAMINE
3-BROMOPYRIDIN-4-AMINE
3-BROMO-PYRIDIN-4-YLAMINE
4-AMINO-3-BROMOPYRIDINE
4-ETHYLPHENYLHYDRAZINE HCL
4-ETHYLPHENYLHYDRAZINE HYDROCHLORIDE
BIO-FARMA BF001075
IFLAB-BB F1371-0140
N'-(4-ETHYL-PHENYL)-HYDRAZINIUM, CHLORIDE
TIMTEC-BB SBB005537 | [EINECS(EC#)]
674-306-3 | [Molecular Formula]
C8H13ClN2 | [MDL Number]
MFCD02068297 | [Molecular Weight]
172.66 | [MOL File]
53661-18-0.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [HS Code ]
29280000 |
| Hazard Information | Back Directory | [Uses]
4-Ethylphenylhydrazine, HCl | [Synthesis]
The general procedure for the synthesis of 4-ethylphenylhydrazine hydrochloride from 4-ethylaniline is as follows: 150 mL of deionized water and 160 mL of 12 N hydrochloric acid were added to a reaction flask containing 24.2 g (0.2 mol) of 4-ethylaniline. After cooling the reaction mixture to 0°C, 14 g (0.2 mol) of sodium nitrite solution dissolved in 140 mL of water was added slowly and dropwise. The reaction temperature was maintained at 0 °C and after 1 h, 112 g (0.496 mol) of stannous chloride dihydrate solution pre-dissolved in 90 mL of 12 N hydrochloric acid was added to the reaction mixture, controlling the temperature of the reaction not to exceed 10 °C during the addition process. After the addition, the reaction was continued with stirring at 10 °C for 1.5 h. The reaction mixture was cooled to 0 °C and then filtered. Upon completion of the reaction, the reaction mixture was filtered and the brown solid product was collected with a measured melting point of 198°C and 95% yield. | [References]
[1] Patent: US2004/43995, 2004, A1. Location in patent: Page 13
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 3, p. 526 - 531
[3] Journal of the Chinese Chemical Society, 2018, vol. 65, # 5, p. 538 - 547
[4] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 137 - 147 |
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